Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to treat patients with acute coronary syndrome, myocardial infarction (MI), peripheral vascular disease and some stroke (ischemic type) patients. Clopidogrel Bisulfate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Plavix is the brand name form of the generic drug clopidogrel bisulfate, an anti-platelet medication that's used to prevent blood clots. Blood clots can form in blood as a result of certain heart. Read about clopidogrel bisulfate (Plavix) a drug to prevent heart attacks, strokes, and to treat peripheral vascular disease and claudication. Plavix is an anti-platelet blood clotting prevention drug. After repeated oral doses of 75 mg of clopidogrel (base), plasma concentrations of the parent compound, which has no platelet-inhibiting effect, are very low and, in general, are below the quantification limit (0.258 µg/l) beyond two hours after dosing. How to use Plavix. Read the Medication Guide provided by your pharmacist before you start taking clopidogrel and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Clopidogrel bisulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It also dissolves freely in methanol, dissolves sparingly in methylene chloride, and is practically insoluble in ethyl ether. 14.3 No Demonstrated Benefit of Clopidogrel plus Aspirin in Patients with Multiple Risk Factors or Established Vascular Disease. CHARISMA. The CHARISMA trial was a 15,603 subject, randomized, double-blind, parallel group study comparing clopidogrel (75 mg daily) to placebo for prevention of ischemic events in patients with vascular disease or. 75 mg PO daily. Clinical practice guidelines recommend single antiplatelet therapy such as clopidogrel for patients with established coronary artery disease (1-year post acute coronary syndrome, with prior revascularization, coronary stenoses 50% by coronary angiogram, and/or evidence for cardiac ischemia on diagnostic testing). Clopidogrel bisulfate, USP is a white to off-white powder. It is freely soluble in methanol, practically insoluble in ether. It has a specific optical rotation of about +56°.